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Identifier

uch.med.phd//1995DIS0055

Title

Ογκογονίδια και περιοχές ενσωμάτωσης ρετροιών στο γονιδίωμα του κυττάρου

Alternative Title

Oncogenes and retroviral insertion sites

Creator

Tsatsanis, Christos A

Abstract

Feline leukaemia virus induces F-cell lymphomas in cat. This is known to occur via insertional mutagenesis. A novel insertion locus of FELV was identified, termed FIT-1.This locus was occupied in 10% of the T-cell lymphomas studied. It was found to collaborate closely with the MYC oncogene. The BMI-1 and PMI-1 oncogenes were also involved in these tumours. Activation of the C-MYC by proviral insertion occured by integration of duplicated proviral LTR elements. This is not the case for the activation of FIT-1 locus.

Issue date

1995-05-01

Date available

1997-06-6

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

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