| Abstract |
The medical records of 96 children who received a hematopoietic stem cell transplant at The University of Texas M.D. Anderson Cancer Center between July 1992 and August 1996 were reviewed for the development of viral infections. Patients were followed for a median of 212 days (range: 15 to 758). Viruses were isolated from 49 patients at a median of 46 days (range: -18 to +630) post-transplant, including CMV (24 patients), VZV (21 patients), HSV (10 patients), adenovirus (4 patients), rotavirus (3 patients), influenza virus (2 patients), RSV (2 patients), parainfluenza virus (1 patient), and enterovirus (1 patient). Thirty nine patients developed a total of 51 episodes of viral illness at a median of 73 days (range: -18 to +630) post-transplant, including 21 with VZV, 10 with HSV, 5 with CMV, 4 with adenovirus, 3 with rotavirus, 2 with influenza virus, 2 with RSV, 1 with parainfluenza virus, and 1 with enterovirus. Five (10%) of the viral illnesses resulted in related deaths. All virus-attributed fatal events were confined within 4 months post-transplant. The greatest fatality was noted with CMV pneumonia (75%). The risk of dying of a viral illness within 2 years post-transplant was 5%. Statistically significant risk factors for the development of viral illness were the development of acute GVHD and the duration of pre-engraftment neutropenia. Risk factors for CMV infection were patient positive CMV serology and the use of bone marrow transplants versus peripheral blood stem cell transplants.
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Ιογενείς λοιμώξεις σε παιδιά με κακοήθη νοσήματα που υποβάλλονται σε μεταμόσχευση αιμοποιητικού ιστού
