E-Locus - Institutional Repository of the University of Crete - Η έκφραση της τελομεράσης ως προγνωστικός παράγων σε όγκους εγκεφάλου

Home Η έκφραση της τελομεράσης ως προγνωστικός παράγων σε όγκους εγκεφάλου

Results - Details

[Add to Basket]

Identifier

000338095

Title

Η έκφραση της τελομεράσης ως προγνωστικός παράγων σε όγκους εγκεφάλου

Author

Γιαννόπουλος, Ανδρέας

Thesis advisor

Μαρκάκης, Ευάγγελος

Reviewer

Χελιδόνης, Ε.
Σπαντίδος, Δημήτριος
Τσιφτσής, Δημήτριος
Γεωργόπουλος, Δημήτριος
Καραμπέκιος, Σ.
De Bree Eelco

Abstract

Telomerase is a reverse transcriptase that maintains telomeres by adding telomeric TTAGGG repeats to the ends of human chromosomes. The aim of this study was to evaluate quantitatively the mRNA expression of telomerase catalytic subunit (hTERT) in different types of intracranial tumors in relation to their histologic pattern and grade and correlate it with progression free (PFS) and overal survival (OS) of patients. hTERT mRNA levels were estimated by the use of real time RT-PCR in 67 samples of intracranial tumors. It revealed statistical correlation between hTERT mRNA expression levels and the grade of the tumors (p&lt0.001). Patients having negative expression of hTERT mRNA had statistically longer progression free survival (p=0.031) and overall survival (p=0.047). Cox univariate regression analysis, revealed that hTERT mRNA- positive patients had a high and statistically significant risk of relapse (HR of 2.24 and p=0.038). In the Cox multivariate regression model the levels of hTERT mRNA were adjusted for tumor grade and patients age and since there was statistically significant relationship between the levels of hTERT mRNA and the grade of the tumors (p=0.003 or p=0.006 respectively), hTERT mRNA levels could not be considered as an independent prognostic factor for PFS or OS.

Language

Greek

Subject

Brain Neoplasms

Glioma

Nervous System

Γλοίωμα

Εγκεφάλου νεοπλάσματα

Νευρικό σύστημα

Issue date

2006-12-20

Collection