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Home    Ανίχνευση συχνοτήτων πολυμορφισμών και παρουσίας των γονιδίων CYP1A1, GSTM1, GSTΤ και CYP19Α1 στο αίμα γυναικών με ενδομητρίωση και ομάδα μαρτύρων  

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Identifier 000338635
Title Ανίχνευση συχνοτήτων πολυμορφισμών και παρουσίας των γονιδίων CYP1A1, GSTM1, GSTΤ και CYP19Α1 στο αίμα γυναικών με ενδομητρίωση και ομάδα μαρτύρων
Author Κουμαντάκης, Γεώργιος Ε
Thesis advisor Σπαντίδος, Δημήτριος
Reviewer Μπούρος, Δ.
Ματαλλιωτάκης, Ιωάννης
Abstract Objective: To investigate the possibility of genetic contribution of CYP1A1, CYP19, GSTM1 and GSTT1 polymorphisms to endometriosis. Design: Genetic polymorphism analysis. Setting: Case control study. Patient(s): A group of 275 sporadic endometriosis cases was compared to a group of 346 fertile endometriosis-free women. Intervention(s): Surgical, laparoscopic and histological examination. Main Outcome Measure(s): Blood specimens were obtained from endometriosis cases and controls. PCR-based assays were performed for the determination of individual's genotype. Result(s): The CYP19 VNTR, located in intron 4, (TTTA)10 allele increase the risk for endometriosis development (odds ratio [OR] 4.99, 95% confidence interval [95% CI] 1.351 to 18.436). The combined genotype CYP1A1 wt/m1 or m1/m1 and GSTM1 null deletion adds to this risk (OR 1.95, 95% CI 1.266 to 2.995 and OR 2.23, 95% CI 0.631 to 7.906, respectively). In contrast, the CYP1A1 wt/wt genotype exhibits a protective effect with a 38% reduction in the odds for endometriosis development (OR 0.62, 95% CI 0.440 to 0.883). Conclusion(s): Our data suggest that CYP19 VNTR (TTTA)10 allele as well as the combined genotype CYP1A1 m1 polymorphism and GSTM1 null deletion associate with the endometriosis phenotype, whereas the GSTT1 null deletion does not. Key Words: Endometriosis, CYP1A1, CYP19, aromatase, GSTM1, GSTT1.
Language Greek
Subject Endometriosis
Gynecology endometriosis
Γυναικολογία Ενδομητριωση
Ενδομητριωση
Issue date 2006-08-04
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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