Your browser does not support JavaScript!

Αρχική    Investigation of tumor growth mechanisms and the interaction with tracheal and hematopoietic system in Drosophila  

Αποτελέσματα - Λεπτομέρειες

Προσθήκη στο καλάθι
[Προσθήκη στο καλάθι]
Τίτλος Investigation of tumor growth mechanisms and the interaction with tracheal and hematopoietic system in Drosophila
Συγγραφέας Μελιγκουνάκη, Αναστασία
Σύμβουλος διατριβής Δελιδάκης, Χρήστος
Περίληψη Drosophila melanogaster is a widely used genetic model organism, with characteristics that enable scientists to study complex pathways involved in biomedical research, including cancer. Notch signaling pathway is one the most commonly deregulated pathways in various diseases and cancer. Notch is a key player in Drosophila brain development and its ectopic over-activation can lead to tumorigenesis with dramatic results. Transcriptomic data from previous work in our lab has shown that after allografting Notch induced brain tumors into adult flies, various genes get up- or down- regulated as the tumor progresses to a more aggressive state. It has been indicated that the tracheal system, the analog of the respiratory system in mammals, plays important role in tumor growth and metastasis (Grifoni et al., 2015, Tamamouna 2021). In the transcriptomic analysis one of the genes that was found upregulated in the most aggressive tumor stage was branchless. Branchless encodes a Drosophila FGF homolog which is important for tracheal cell migration and branching (Sutherland et al., 1996). Considering the above results, our study attempts to clarify the interplay between tumor and the tracheal system in adult Drosophila with a focus on the FGF/FGFR homologs, branchless and breathless. As tumor progresses over time, another gene that gets upregulated is Tep4. Tep4 is a thioester-containing protein which is involved in immune responses in Drosophila and other insects by promoting recruitment of immune cells in response to infections (Shokal & Eleytherianos, 2017). In this work, we examine the expression of Tep4 in the larval and adult stages and we try to define the differential expression pattern upon tumorigenic conditions. Finally, guided by the transcriptomic data along with immunohistochemistry, we have observed that Drosophila blood cells respond to allografted tumors. Here we wanted to investigate the response of the larval hemocytes in the primary brain hyperplasia by examining the proliferation rate of hemocytes and their differentiation into distinct subtypes.
Γλώσσα Αγγλικά
Ημερομηνία έκδοσης 2022-03-28
Συλλογή   Σχολή/Τμήμα--Σχολή Θετικών και Τεχνολογικών Επιστημών--Τμήμα Βιολογίας--Πτυχιακές εργασίες
  Τύπος Εργασίας--Πτυχιακές εργασίες
Εμφανίσεις 30

Ψηφιακά τεκμήρια
No preview available

Κατέβασμα Εγγράφου
Προβολή Εγγράφου
Εμφανίσεις : 5