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Identifier uch.med.phd//1994liloglou
Title Μελέτη της δραστικότητας γλυκολυτικών ενζύμων κατά την εξαλλαγή κυττάρων με το ογκογονίδιο T24-H-RAS
Alternative Title Study of the activity of glucolytic enzymes during cell transformation with the T24-H-RAS oncogene
Creator Liliglou, Triantafillos N
Abstract The aim of the study was to eludicate the role of the H-RAS ongogene in the regulation of glycolytic enzymes, since glycolysis is thought to be the main energy source of tumor cells. We develooped for this reason rat fibroblast and epithelial cell lines in which transcription of the exogenous human T24-H-RAS gene is regulated by addition of IPTG in the culture medium. We found that overexpression of H-RAS leads to activation of phosphoglycerate kinase, enolase and pyruvate kinase in fobroblasts but not in epithelial cells. This activation, however, did not result in alteration of the total glycolytic rate. We propose that these activations concern non glycolytic function of the above enzymes, as have been recently described.
Issue date 1994-12-01
Date available 1997-06-6
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
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