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Identifier

000388694

Title

Συμπεριφορική μελέτη νέων φαρμακολογικών ουσιών σε ένα διαγονιδιακό μοντέλο για τη νόσο Αλτσχαϊμερ

Alternative Title

Behavioral screening of novel pharmacological agents in a transgenic mouse model for Alzheimers disease

Author

Παπακωνσταντίνου Ηλέκτρα

Thesis advisor

Δάλλα, Χριστίνα

Abstract

The aim of the current study was to investigate the effects of compound Oleuropein, on the behavioral phenotype of an AD mouse model (3xTg) which expresses mutated forms of human proteins Tau, APP and Presenilin1. This model exhibits the main pathological aspects of AD. The behavioral screening included the open field, light/dark, Y maze, novel object recognition and tail suspension tests. The 3xTg mice exhibit reduced locomotor activity, which were not reversed by Oleuropein. Howevern oleuropein treatment resulted in the improvement of the reduced exploratory activity of 3xTg mice towards a novel environment. Sex differences were observed in stereotypic behavior of 3xTg mice. Anxiety levels and “depression-like” behavior did not affected by genotype, gender or treatment. In novel object recognition task 3xTg mice showed mild cognitive deficits, which were reversed by Oleuropein treatment.

Language

Greek

Subject

3x Tg mice

Alzhemers disease

Oleuropein

Νόσος Αλτσχάιμερ

Ολευρωπαϊκή

Issue date

2014-12-04

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses