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Identifier

uch.chemistry.phd//1995DIS0169

Title

Σύνθεση και μελέτη βιολογικής δραστηριότητας παραγώγων του 2-άμινο-1,2,3,4-τετράυδρο-1,4-εποξυναφθαλενίου και 2,3,6,7A,8,12B,12C-οκτάυδρο-1H,5H,-νάφθο[1,2,3,I,J]κινολιζίνης, δύσκαπτων αναλόγων της ντοπαμίνης

Alternative Title

Synthesis and biological studies of 2-amino-1,2,3,4-tetrahydro-1,4-epoxynaphthalene and 2,3,6,7A,12B,12C-octahydro-1H,5H-naphtho[1,2,3,I,J]quinolizine, rigid analogues of dopamine

Author

Κουβαράκης, Αντώνης Ν

Abstract

In this thesis is described the synthetic methodology tha was chosen for the preparation of a series of dopamine (DA) analogues. The first group includes the synthesis of a series of analogues of 2-amino-1,2,3,4-tetrahydro-1,4-epoxy-naphthalene. These compounds can be considered as analogues of the DA-active compound ADTN. The second group includes the total diastereoselective synthesis of the tetracyclic analogue of Dopamine 2,3,6,7a,8,12b,12c-octahydro-1h,5h-naphtho[1,2,3,i,j]quinolizine with trans-cis fusion of the ring B/C and B/D respectively. The results of biological studies of these compounds are discused in basis of the relation between their structural characteristics and their activity.

Language

Greek

Issue date

1995-04-01

Date available

1997-06-6

Collection

School/Department--School of Sciences and Engineering--Department of Chemistry--Doctoral theses

Type of Work--Doctoral theses

Views

579

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