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Title

Διερεύνηση της έκφρασης και λειτουργικότητας του πυρηνικού CSF-1R σε ορμονοεξαρτώμενα και μη ορμονοεξαρτώμενα καρκινικά κύτταρα μαστού

Author

Αράπη, Βασιλική

Thesis advisor

Παπακωνσταντή, Ευαγγελία

Abstract

CSF-1 (Colony-stimulating factor-1) is a multifunctional growth factor whose effects are mediated by the CSF-1 receptor (CSF-1R), a receptor tyrosine kinase encoded by the c-fms proto-oncogene. Many studies have shown that CSF-1 and CSF-1R have roles not only in the hematopoietic system but also in systems correlating with cancer biology. Indeed, abnormal expression of CSF-1R, with or without CSF-1, has been documented in a wide variety of human carcinomas and carcinoma-derived cell lines, including tumors of epithelial origin such as carcinomas of breast, ovarian, cervical, endometrial, lung, kidney, pancreas, and prostate. In the current project an attempt was made to investigate the expression and functionality of the nuclear CSF-1R in hormone-dependent and hormone-independent breast cancer cell lines potentially establishing CSF-1R as a valuable tumor biomarker and/or a novel target for the diagnosis and treatment of cancer. More specifically the effect of estradiol in the absence or presence of CSF-1 was examined, on the expression and / or activity of nuclear CSF-1Rs. The results obtained suggest that the nuclear CSF-1R may be implicated in the development of cancer and that nuclear CSF-1R could potentially become a novel target for the diagnosis and treatment of cancer.

Language

Greek

Subject

Macrophage Colony

SDS

Western Blot

Βιολογικό υλίκο

Οιστρογόνα

Issue date

2012-02-01

Collection

School/Department--School of Sciences and Engineering--Department of Biology--Graduate theses