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Identifier 000434221
Title Exons going in circles: computational approaches reveal universal genomic architecture design of the CircExons
Alternative Title Εξόνια που κάνουν κύκλους: υπολογιστικές προσεγγίσεις αποκαλύπτουν γενικό γενομικό αρχιτεκτονικό σχεδιασμό των κυκλικών εξονίων.
Author Βαραμογιάννη Μαμάτση, Βασιλική Α.
Thesis advisor Νικολάου, Χριστόφορος
Reviewer Παυλίδης, Παύλος
Ηλιόπουλος, Ιωάννης
Abstract Circular Exons (or CircExons) are single stranded RNA molecules, covalenty closed and belonged to the category of circRNAs (non conding RNAs). The mechanism of their production is assumed to be a special form of RNA splicing, called Back-Splicing, where the splicing machinery ligates a downstream splice donor site reversely with an upstream splice acceptor site, forming a 3-5 phosphodiester bond. In addition, CircExons are not randomly produced but each cell line produces specific CircExons. However, the mechanisms that result in this kind of strict recognition and production of the circular exons are remained unknown. In the present study, which was accomplished in the context of the Master Program ”Molecular Biology and Biomedicine”, is presented a genomic architecture pattern which corresponds to different human cell types and concerns DNA sequence and nucleosome positioning. In particular, here we support that CircExons present lower GC content but stronger nuclesome positioning than linear exons. Additionally, we believe that upstream linear exons (the circular ones) play a key role in signaling circular exons. These patterns seem to represent a universal genomic design for the human CircExon recognition and probably justifies the phenomenon of back splicing, instead of other forms of alternative splicing.
Language English
Subject Back splicing
Circular RNA
GC content
Homo sapiens
Real time detection
Ανάποδο μάτισμα
Κυκλικά εξόνια
Κυκλικό RNA
Περιεκτικότητα GC
Issue date 2020-11-27
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
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