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Identifier 000426440
Title Promyelocytic Leukemia Protein (PML) regulates epithelial – mesenchymal transition & tumorigenicity in breast cancer models
Alternative Title Η PML ρυθμίζει την επιθηλιομεσεγκυματική μετάβαση και την ογκογένεση σε μοντέλα καρκίνου του μαστού
Author Δημακοπούλου, Μυρσίνη-Αναστασία Γ.
Thesis advisor Παπαματθαιάκης, Ιωσήφ
Reviewer Νικολάλου, Χριστόφορος
Κρετσόβαλη, Ανδρονίκη
Abstract Promyelocytic leukemia protein (PML) is a multifunctional protein, as it is implicated in a wide range of biological processes, including DNA – damage response, apoptosis, senescence and angiogenesis. PML also displays a contradictory role in the development of cancer, as both tumor – suppressor and pro - survival roles have been attributed to its function, depending the system of study. Here, we compare two breast cancer cell lines: the triple-negative, mesenchymal MDA.MB.231 and the luminal A, epithelial MCF7 in order to detect the effect of PML silencing in cell growth, epithelial-mesenchymal transition and tumorigenisity. Through in vitro cultures and an in vivo mouse experimental model it is shown that upon PML knockdown MDA.MB.231 favor a more aggressive character, with a higher capability to form tumors and metastatic foci, whereas MCF7 tend to acquire a mesenchymal phenotype with increased migratory and invasive ability.
Language English
Subject EMT
Oncogenesis
Πρωτεΐνη Προμυελοκυτταρικής Λευχαιμίας
Issue date 2019-11-29
Collection   Faculty/Department--Faculty of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/c/3/e/metadata-dlib-1575284219-69827-18361.tkl Bookmark and Share
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