Μεταπτυχιακές εργασίες ειδίκευσης
Τρέχουσα Εγγραφή: 6 από 802
|
Κωδικός Πόρου |
000463264 |
Τίτλος |
Synthesis, characterisation and 3D-printing of responsive biodegradable polymers for regenerative medicine applications |
Άλλος τίτλος |
Σύνθεση, χαρακτηρισμός και τριδιάστατη εκτύπωση αποκρίσιμων βιοδιασπώμενων πολυμερών με εφαρμογές στην αναγεννητική ιατρική |
Συγγραφέας
|
Βρέντζου, Μυρτώ Ε.
|
Σύμβουλος διατριβής
|
Βαμβακάκη, Μαρία
|
Μέλος κριτικής επιτροπής
|
Χατζηνικολαΐδου, Μαρία
Μητράκη, Μαρία
|
Περίληψη |
Aliphatic polyesters comprise a group of richly diverse polymers with applications in many
medical fields and tools, such as sutures, bone screws, drug delivery carrier systems and tissue
engineering. These materials bear useful characteristics, such as enhanced biocompatibility
and biodegradability. However, they are generally inert, without specific functionalities that
would provide them with extra biological and responsive characteristics.
Thus, this thesis project focuses on the preparation of multifunctional pH-responsive
biodegradable polyesters for tissue engineering applications. In particular, polyesters with
carboxylic acid and alkene side groups were developed and studied. The carboxylic acid side
groups provide pH-responsive properties and will enhance the hydrophilicity of the polyester,
while the alkene side groups can be further used to covalently bind bioactive molecules and
aid the formation of stable hydrogels.
The soft and rubbery texture of these polymer networks closely resembles that of a tissue’s
natural extracellular matrix. This makes them excellent candidates to be used as surrogate
matrices for cell growth that more faithfully recapitulate the native, three-dimensional
microenvironment of a cell, as opposed to the alterations in cell development driven by stiff,
two-dimensional cell culture materials.
Therefore, the biodegradable, biocompatible, functional polyesters that were synthesised in
this thesis project were tested and used as a bio-ink for the fabrication of cell-friendly, tissue
engineering scaffolds. Extrusion-based additive manufacturing methods were employed for
hydrogel printing, with the occasional addition of a nano-silicate clay (laponite) as rheology
modifiers to improve texture and printability. The resulting scaffolds of different shapes and
sizes were studied to determine swelling and porosity properties. Finally, the hydrogels were
subjected to cell development and viability assays in a closely monitored cell culture
environment.
|
Φυσική περιγραφή |
66 σ. : πίν., σχήμ., εικ. (μερ. εγχρ.) ; 30 εκ. |
Γλώσσα |
Αγγλικά |
Θέμα |
Bone |
|
Characterization |
|
Polyester |
|
Regenerative medicine |
|
Tissue engineering |
|
Αποκρίσιμα πολυμερή |
|
Οστά |
|
Πολυεστέρες |
|
Πολυμερές |
|
Σύνθεση |
|
Σύνθεση πολυμερών |
|
Χαρακτηρισμός |
Ημερομηνία έκδοσης |
2024-03-29 |
Συλλογή
|
Σχολή/Τμήμα--Σχολή Θετικών και Τεχνολογικών Επιστημών--Τμήμα Βιολογίας--Μεταπτυχιακές εργασίες ειδίκευσης
|
|
Τύπος Εργασίας--Μεταπτυχιακές εργασίες ειδίκευσης
|
Μόνιμη Σύνδεση |
https://elocus.lib.uoc.gr//dlib/3/9/8/metadata-dlib-1710433686-663413-20014.tkl
|
Εμφανίσεις |
110 |