Post-graduate theses
Current Record: 25 of 802
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Identifier |
000460387 |
Title |
Responsive protein-polymer conjugate nanoparticles for drug delivery |
Alternative Title |
Νανομεταφορείς αποκρίσιμων βιοσυζύγων πρωτεΐνης-πολυμερούς για μεταφορά φαρμάκων |
Author
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Χαριτάκη, Μυρτώ Ε.
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Thesis advisor
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Βελώνια, Κέλλυ
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Reviewer
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Φαρσάρη, Μαρία
Ρανέλλα, Ανθή
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Abstract |
Nanoparticles (NPs) as Drug Delivery systems have drawn significant interest in the field of
nanomedicine. Responsive nanoparticles in particular are a very promising class of drug
delivery nanovesicles with the ability to release a therapeutic cargo under specific stimuli.
Targeted drug release from responsive nanoparticles can be a useful tool to the drug
administration in the acidic environment of cytoplasm in cancer cells as well as low pH of
different organelles (lysosomes).
The research performed during this study was based on the development and evaluation of
three different types of responsive NPs (pH-, temperature- and dual- responsive NPs) and in
particularly focused on the drug loading and release study of pH-responsive NPs. More
specifically different monomers (i.e., DMAEMA, DPA and NIPAM) were grafted from albumins
(has and BSA) via an oxygen tolerant, copper-mediated controlled radical polymerization
approach, resulting in responsive self-assembled nanoparticles. The response of albumin-
responsive polymer NPs was studied under specific stimuli (pH or temperature). Model-drug
dye molecules such as Eosin Y, fluorescein and acridine orange and a model therapeutic
enzyme (pepsin) and chemotherapeutic drugs (5-fluorouracil, oxaliplatin, natural compounds
with anticancer properties), were encapsulated in the responsive nanoparticles in the scope
of studying their encapsulation efficiency, loading capacity and drug release.
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Language |
English |
Subject |
Bioconjugates |
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Responsive polymersP |
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Αποκρίσιμα πολυμερή |
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Βιοσυζυγή |
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Νανοσωματίδια |
Issue date |
2023-11-24 |
Collection
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School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/6/d/9/metadata-dlib-1700038913-879255-15490.tkl
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Views |
991 |
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