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Identifier uch.biology.msc//2004gligoris
Title Μελέτη νέων αλληλεπιδράσεων και νέων ρόλων του συμπλόκου συγκαταστολέα της μεταγραφής Ssn6-Tup1 του S.cerevisiae
Creator Gligoris, Thomas
Abstract The main target of the current thesis was the verification and initial functional analysis of putative new interactants of the global transcriptional yeast co-repressor complex Ssn6-Tup1. The interaction with the 60S ribosomal subunit export adaptor Nmd3 as well as a rather unexpected 60S accumulation phenotype and irregular polysomal profile is demonstrated. Moreover exploring the Tup1 localization it’s positioning on the nuclear periphery was revealed, possibly relating the co-repressor with events around the nuclear pore. Last, a mini library of putative Ssn6 chromatin binding sites was developed in order to explore in future time new promoter targets of the co-repressor.
Issue date 2004-11-01
Date available 2004-12-09
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/6/1/5/metadata-dlib-2004gligoris.tkl Bookmark and Share
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