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Identifier uch.biology.msc//2004bazopoulou
Title Μέρος Α: Degenerins, μνήμη και μάθηση στον C. elegans Μέρος Β: Μετάθεση του στοιχείου Minos στον C. elegans
Creator Bazopoulou, Maria-Daphni
Abstract Members of the EG/ENaC family of ion channel subunits have been identified in organisms ranging from nematodes, flies, snails and many vertebrates including humans and are expressed in tissues as diverse as kidney, epithelia, muscles and neurons (reviewed in (Kellenberger and Schild 2002). While DEG/ENaC proteins are involved in many diverse biological functions in different organisms (mechanotransduction, locomotion, Na+ homeostasis, pain perception) they share a highly conserved overall structure (Benos and Stanton 1999; Kellenberger and Schild 2002; Syntichaki and Tavernarakis 2004), which suggests that they shared a common ancestor relatively early in evolution. The basic subunit structure may have been adapted to fit a range of biological needs by the addition or modification of functional domains. Recently there were indications for the involvement of DEG/ENaC family members in associative learning and memory. This study intends to confirm the new role of these proteins. The variety of DEG/ENaC proteins identified in C. elegans (known as dgenerins), the well characterized neuronal system and the behavioral assays can contribute in the detection of the role of degenerins in associative learning and memory and in the investigation of the mechanism involved. Indeed, learning and memory assays (chemiotaxis after conditioning) showed an implication of a non characterized degenerin of C. elegans, (ZK770.1) in these neuronal processes.
Issue date 2004-11-01
Date available 2005-01-10
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/5/d/6/metadata-dlib-2004bazopoulou.tkl Bookmark and Share
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