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Identifier uch.biology.phd//1998DIS0488
Title Regularity networks involved in the determination and maintenance of the hepatic phenotype
Alternative Title Μεταγραφικά ρυθμιστικά δίκτυα που σχετίζονται με τον καθορισμό και τη διατήρηση του ηπατικού φαινότυπου
Author Κτιστάκη, Ελένη
Thesis advisor Ταλιανίδης, Ι.
Abstract Mechanisms which govern development and organogenesis are a major issue in biology. These mechanisms are mainly determined by a cascade of events which include specific spatiotemporal activation of a subset of genes. In such a cascade, transcription factors play a crucial role since they carry specific messanges to the DNA, which result in the activation of specific set of genes. The model system we are studying is the hepatocyte phenotype which haw proven to be very attractive for biochemical, cellular and developmental studies HNF4 is a prominent member of liver enriched transcription factors, playing a role in the expression of a large number of liver specific genes. We have found that HNF4 is a phosphoprotein and that phosphorylation at tyrosine residue is a prerequisite for its DNA binding and transactivation potential. HNF4 was also found to colaborate via protein-protein interactions with two other transcription factors -HNF1 and COUP-IFs - to regulare gene expression in some cases. Thus, HNF4 is necessary but not sufficient for hepatic gene expression.
Language Greek
Subject Ηπατοειδική έκφραση γονιδίων, ηπατοειδικοί μεταγραφικοί παράγοντεσ, αλληλεπιδράσεις μεταγραφικών παραγόντων, ενδοπυρηνική τοποθέτηση μεταγραφικών παραγόντων, φωσφορυλίωση σε τυροσίνη, ιεραρχία μεταγραφικών και μετα-μεταφρατικών ρυθμίσεων, hepatic gene expression, hepatocyte specific transcription factors, interactions between transcription of transcription factors, tyrosine phosphorylation, transcriptional and post-translational hierarchie
Issue date 1998-04-02
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/1/4/2/metadata-dlib-1998DIS0488.tkl Bookmark and Share
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