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Identifier 000460361
Title Σχεδιασμός, ανάπτυξη και αξιολόγηση νέων φθοροφόρων
Alternative Title Design, development and evaluation of new fluorophores
Author Αδάμης, Κωνσταντίνος Σ.
Thesis advisor Νεοχωρίτης, Κωνσταντίνος
Reviewer Στρατάκης, Μανώλης
Ελευθεριάδης, Νικόλαος
Abstract The purpose of this work is the design, synthesis and characterization of new fluorescent substances, via Multicomponent Reactions (MCRs), aiming to find new, covalent and non-covalent, protein inhibitors for the imaging of those, by fluorescence spectroscopy techniques. The reactions that were used are the Groebke-Blackburn-Bienaymé (GBB-3CR), Passerini (P-3CR), Ugi-Tetrazole (UT-4CR) and the Ugi Classical (U-4CR) reactions. Through modification of the molecule of fluorescein, which was used as the initial fluorescent source, between others, its integration into the backbone of the specific reactions was achieved. In addition, the absorption and emission spectra of these compounds were obtained. The products were synthesized to retain their fluorescence capacity, but due to the backbone of each reaction and the different functional groups that are contained, to be able to selectively target and highlight various biological targets.
Language Greek
Subject Coumarin
Fluorescein
Fluorescent substances
Groebke-Blackburn-Bienaymé (GBB-3CR)
Isocyanide
Multicomponent reactions (MCRs)
Passerini (P-3CR)
UV-Vis spectroscopy
Ugi Classical (U-4CR)
Ugi-Tetrazole (UT-4CR)
Αντιδράσεις πολλών συστατικών (MCRs)
Ισονιτρίλιο
Κουμαρίνη
Φασματοσκοπία UV-Vis
Φθορίζουσες ουσίες
Φλουορεσίνη
Issue date 2023-11-23
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/4/5/a/metadata-dlib-1699948414-482802-11601.tkl Bookmark and Share
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