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Doctoral theses

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Identifier 000454996
Title Porphyrins for medical and photocatalytic applications
Alternative Title Σύνθεση πορφυρινικών συμπλόκων για ιατρικές και φωτοκαταλυτικές εφαρμογές
Author Λάνδρου, Γεώργιος Κ.
Thesis advisor Κουτσολέλος, Αθανάσιος
Reviewer Ταβερναράκης, Νεκτάριος
Κυμάκης, Εμμανουήλ
Μητράκη, Άννα
Κιτσόπουλος, Θεοφάνης
Μήλιος, Κωνσταντίνος
Λαδωμένου, Καλλιόπη
Abstract The present Doctoral Thesis describes the synthesis of new chromophores, and their utilization in photocatalytic and medical applications. Particularly, several water- soluble porphyrins and carbon dots are examined as photosensitizers, combined either with catalysts for hydrogen (H2) production or Fmoc-protected dipeptides for antimicrobial and wound healing applications. More specifically, the simple synthetic approaches, attractive photophysical properties, and solubilization in the water of the prepared chromophores are the key parameters for the presented applications. The characteristic Pyridyl groups in the meso-position of the synthesized porphyrins offer water-solubility upon methylation. Different central metal ions, such as zinc, tin, cobalt, and nickel transform the properties of the resulting porphyrin derivatives. On the other hand, carbon dots as light harvesters offer distinctive properties and low-cost preparation. Moreover, the passivation of the surface of these materials with Nitrogen sources can modify their properties. This dissertation is divided into two main sections. The first section was inspired by natural photosynthesis. More specific, water-soluble chromophores were combined with molecular Cobalt and Nickel catalysts to transform protons into Η2. Various factors that determine the efficiency of the photocatalytic system are evaluated, in order to maximize H2 production. Namely, some representative parameters that were explored are: the charge of the porphyrin derivatives, the buffer solution, the light source, the ratio between the photosensitizer and the catalyst. Furthermore, extensive photophysical and electrochemical investigation was conducted in order to determine the mechanism of the phorocatalytic H2 production. Interestingly, except for utilizing only commercial light sources, actual solar irradiation uner sunlight was applied targeting to obtain important observations for future uses. The next section deals with the incorporation of the water-soluble chromophores in hydrogel networks formed by Fmoc-protected dipeptides, through intermolecular interactions. The formatted hydrogels are used in advanced antimicrobial applications in bacteria and worms such as C. elegance. Numerous studies are carried out, such as cytotoxicity and visible light affection in the resulting hydrogels. Finally, the wound healing application of the formatted hydrogels on the Wistar rat's skin is examined. The wound healing process is studied both in young and old animals for a comprehensive results analysis. Controlling the effectiveness of the resulting hydrogels will provide valuable results for future clinical studies.
Language English
Subject Antimicrobial
Carbon dots
Chromophores
Hydrogels
Hydrogen production
Natural photosynthesis
Porphyrin
Self-assembly
Wound healing
Αντιμικροβιακή δράση
Επούλωση πληγών
Νανοτελείες Άνθρακα
Παραγωγή Υδρογόνου
Πορφυρίνη
Υδρογέλες
Φωτοσύνθεση
Χρωμοφόρα
Issue date 2023-07-13
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/1/9/8/metadata-dlib-1682493086-523450-1181.tkl Bookmark and Share
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