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Title

Scaffold fabrication using laser irradiation for cell cultivation

Alternative Title

Κατασκευή ικριωμάτων με την χρήση ακτινιβολίας λέιζερ για την καλλιέργεια κυττάρων

Author

Γαβαλάς, Ιάκωβος

Thesis advisor

Μητράκη, Άννα
Φαρσάρη, Μαρία

Abstract

One of the most promising techniques of 3D scaffold fabrication for cell culture is the two-photon polymerization technique. This method allows the fabrication of micrometer size structures with submicron resolution. In this study, a photosensitive sol-gel hybrid material, zirconium doped silicate has been studied for its suitability in three dimensional scaffold fabrication. The fabrication of 3D scaffold for cell alignment, directional growth and glial-like carpet formation, is presented. This hybrid material provides a matrix for cell growth (organic part) and mechanical stability to the structure (inorganic part). The use of femtosecond laser structuring permits the fabrication of a wide range of mechanically stable scaffolds of different sizes and shapes to be tested in terms of cell viability, proliferation and orientation.

Language

Greek

Subject

Direct laser writing

Neural cells

Two photon absorption

Issue date

2016-03-18

Collection

School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Graduate theses

Type of Work--Graduate theses

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