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Title The study of self-assembled peptides and their Copper-binding complexes
Alternative Title Μελέτη των αυτοοργανώμενων πεπτιδίων και των συμπλόκων τους με χαλκό
Author Καραμεσούτη Αγγελίνα
Thesis advisor Μητράκη, Άννα
Abstract Natural biomolecules, like peptides and proteins, are building blocks of natural biomaterials due to their ability to self-assemble through intermolecular interactions, forming various micro- and nanoscale structures such as fibrils and hydrogels. Hydrogels are three-dimensional, crosslinked hydrophilic networks of natural or synthetic polymers, which have the ability to store large amounts of water or other biological fluids. In this diploma thesis, the self-assembly of the copper-binding tripeptides GGH (Glycine-Glycine-Histidine) and GHK (Glycine- Histidine-Lysine) was examined, using a variety of solvents under a range of conditions. Additionally, peptide mixtures were studied in order to examine the interactions between them, as well as their propensity for co-assembly. Finally, as the imidazole ring of histidine can be coordinated to a wide variety of divalent metal ions, we conducted experiments with copper cations Cu2+ in order to study the impact of histidine-metal coordination on the self-assembly process of the peptides.
Language Greek
Issue date 2022-11-23
Collection   School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Graduate theses
  Type of Work--Graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/a/e/6/metadata-dlib-1673861846-643-31693.tkl Bookmark and Share
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