Graduate theses
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Current Record: 9 of 67
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Title |
The study of self-assembled peptides and their Copper-binding complexes |
Alternative Title |
Μελέτη των αυτοοργανώμενων πεπτιδίων και των συμπλόκων τους με χαλκό |
Author
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Καραμεσούτη Αγγελίνα
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Thesis advisor
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Μητράκη, Άννα
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Abstract |
Natural biomolecules, like peptides and proteins, are building blocks of natural
biomaterials due to their ability to self-assemble through intermolecular interactions,
forming various micro- and nanoscale structures such as fibrils and hydrogels.
Hydrogels are three-dimensional, crosslinked hydrophilic networks of natural or
synthetic polymers, which have the ability to store large amounts of water or other
biological fluids. In this diploma thesis, the self-assembly of the copper-binding
tripeptides GGH (Glycine-Glycine-Histidine) and GHK (Glycine- Histidine-Lysine)
was examined, using a variety of solvents under a range of conditions. Additionally,
peptide mixtures were studied in order to examine the interactions between them, as
well as their propensity for co-assembly. Finally, as the imidazole ring of histidine can
be coordinated to a wide variety of divalent metal ions, we conducted experiments
with copper cations Cu2+ in order to study the impact of histidine-metal coordination
on the self-assembly process of the peptides.
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Language |
Greek |
Issue date |
2022-11-23 |
Collection
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School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Graduate theses
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Type of Work--Graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/a/e/6/metadata-dlib-1673861846-643-31693.tkl
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Views |
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