Post-graduate theses
Current Record: 22 of 123
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Identifier |
000453109 |
Title |
Synthesis of functional protein-polymer conjugates and biodegradable polymers |
Alternative Title |
Σύνθεση λειτουργικών υβριδίων πρωτεϊνης πολυμερούς και βιοδιασπώμενων πολυμερών |
Author
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Μπαλτζάκη, Μαρία Χρυσή Ιζαμπέλλα
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Thesis advisor
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Βελώνια, Καλλιόπη
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Reviewer
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Αρματάς, Γεράσιμος
Ρανέλλα, Ανθή
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Abstract |
Protein-polymer conjugates are biohybrid macromolecules designed to combine the functionality, activity and selectivity of biomolecules with the stability and vast chemical diversity of synthetic polymers. Such protein-polymer chimeras can either retain their original features or display new physical and/or chemical properties not seen in the individual moieties -such as phase separation or self-assembling behaviour- while, at the same time the stability, biocompatibility and solubility of the parent protein can be potentially improved. In the past few years, protein-polymer conjugates have gained interest due to their potential for applications in many fields ranging from nanotechnology to biomedicine.
Recently, oxygen-tolerant, copper-mediated (photo)polymerization approaches were developed for the grafting of a variety of monomers from different proteins without the need for deoxygenation or other tedious reaction conditions. This Thesis contributed to the evaluation of the optimal conditions of an oxygen-tolerant, aqueous copper-mediated polymerization approach, and its scaling up. Aiming to expand the scope, the grafting from different proteins was explored. More importantly, based on this synthetic method, an alternative, ligand-free synthetic procedure was developed to readily afford protein-polymer bioconjugates. A plethora of monomers including styrene, acrylates, methacrylates, acrylamides and renewable monomers were grafted from protein macroinitiators to yield a wide variety of biohybrids with amphiphilic or hydrophilic character as well as triblock bioconjugates exhibiting interesting self-assembling patterns.
In parallel, in the context of the “Biowaste to Bioplastic” program B2B, PLLA was synthesised via azeotropic dehydration followed by polycondensation polymerization and characterized.
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Language |
English |
Subject |
Βιοδιασπώμενα πολυμερή |
Issue date |
2022-11-23 |
Collection
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School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/6/0/3/metadata-dlib-1672823864-492664-13875.tkl
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Views |
403 |
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