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Identifier

000461897

Title

3D mechanical metamaterials

Alternative Title

Τρισδιάστατα μηχανικά μετα-υλικά

Author

Σκρεπετός, Σταύρος

Thesis advisor

Φαρσάρη, Μαρία

Reviewer

Ρανέλλα, Ανθή
Βελώνια, Καλλιόπη

Abstract

This study highlights the integration of metamaterials into tissue engineering, leveraging expertise from physical sciences, computational modeling, and mechanical biology. Mechanical metamaterials offer unique advantages for controlling the mechanical environment of cells and tissues, including the creation of specialized cellular structures and properties. The primary objective was to design precise spherical mechanical metamaterials with rare auxetic behavior, achieved through algorithmic engineering facilitated by the Hyperganic software. The spheres were fabricated with high precision using advanced 3D printing and optically characterized through scanning electron microscopy (SEM). Multi – Photon lithography enabled the construction of intricate microscale structures, particularly the fabrication of 400 μm-diameter spherical scaffolds. These scaffolds are promising for supporting cell growth without compromising viability, making them valuable for tissue engineering. Characterization involved numerical simulations using ANSYS and SolidWorks and mechanical testing with the MicroTester LT to calculate key properties. Mesenchymal stem cells were seeded on the scaffolds and assessed over multiple days. Precise 3D analysis was made possible through a confocal microscope, allowing a deep understanding of these innovative metamaterial-based tissue engineering solutions.

Language

English

Subject

Two-photon lithography

Διφωτονική λιθογραφία

Ιστομηχανική

Issue date

2024-03-22

Collection

School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Post-graduate theses

Type of Work--Post-graduate theses

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