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Identifier 000453109
Title Synthesis of functional protein-polymer conjugates and biodegradable polymers
Alternative Title Σύνθεση λειτουργικών υβριδίων πρωτεϊνης πολυμερούς και βιοδιασπώμενων πολυμερών
Author Μπαλτζάκη, Μαρία Χρυσή Ιζαμπέλλα
Thesis advisor Βελώνια, Καλλιόπη
Reviewer Αρματάς, Γεράσιμος
Ρανέλλα, Ανθή
Abstract Protein-polymer conjugates are biohybrid macromolecules designed to combine the functionality, activity and selectivity of biomolecules with the stability and vast chemical diversity of synthetic polymers. Such protein-polymer chimeras can either retain their original features or display new physical and/or chemical properties not seen in the individual moieties -such as phase separation or self-assembling behaviour- while, at the same time the stability, biocompatibility and solubility of the parent protein can be potentially improved. In the past few years, protein-polymer conjugates have gained interest due to their potential for applications in many fields ranging from nanotechnology to biomedicine. Recently, oxygen-tolerant, copper-mediated (photo)polymerization approaches were developed for the grafting of a variety of monomers from different proteins without the need for deoxygenation or other tedious reaction conditions. This Thesis contributed to the evaluation of the optimal conditions of an oxygen-tolerant, aqueous copper-mediated polymerization approach, and its scaling up. Aiming to expand the scope, the grafting from different proteins was explored. More importantly, based on this synthetic method, an alternative, ligand-free synthetic procedure was developed to readily afford protein-polymer bioconjugates. A plethora of monomers including styrene, acrylates, methacrylates, acrylamides and renewable monomers were grafted from protein macroinitiators to yield a wide variety of biohybrids with amphiphilic or hydrophilic character as well as triblock bioconjugates exhibiting interesting self-assembling patterns. In parallel, in the context of the “Biowaste to Bioplastic” program B2B, PLLA was synthesised via azeotropic dehydration followed by polycondensation polymerization and characterized.
Language English
Subject Βιοδιασπώμενα πολυμερή
Issue date 2022-11-23
Collection   School/Department--School of Sciences and Engineering--Department of Materials Science and Technology--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/6/0/3/metadata-dlib-1672823864-492664-13875.tkl Bookmark and Share
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