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Identifier

000457482

Title

The incidence of KRAS G12D in colon cancer

Alternative Title

Η επίπτωση του KRAS G12D στον καρκίνο παχέος εντέρου

Author

Χλωράκης , Γεώργιος

Thesis advisor

Κουμαριανού, Άννα

Reviewer

Βασιλακοπούλου, Μαρία
Πίντζας, Αλέξανδρος

Abstract

Colorectal cancer (CRC) is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women. Mutations in the KRAS gene occur in 40–52% of CRC cases which are also noted in nearly one-quarter of a wide spectrum of cancers. Herein is presented the physiological role of the RAS protein and the detailed downstream cascade after its activation. The analysis of this signalling pathway gives an insight into its actions, thus facilitating the development of inhibitors to block tumorigenesis. There are multiple mutations in residues 12, 13, 61, and 146 of this gene and they play a critical role in tumorigenesis. Specific substitutions such as the G12D are targets of antitumor therapies. Furthermore, the identification of the mechanisms that cause intracellular protein trafficking has suggested several potential therapeutic approaches. KRAS is an important prognostic factor and a predictive marker in determining resistance to epidermal growth factor receptor (EGFR) inhibitors. Here are several ongoing clinical trials of compounds that impede either the activation or the protein-membrane interaction or one of the three main signalling pathways of the KRAS cascade.

Language

English

Subject

Colorectal

Mutation

Μετάλλαξη

Ορθοπρωκτικός

Issue date

2023-07-28

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses