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Identifier 000429181
Title Association of maternal diet during early pregnancy and risk of gestational diabetes. The role of maternal metabolic profile and mental health: data from RHEA study, Crete.
Alternative Title Συσχέτιση της διατροφής στην αρχή της εγκυμοσύνης με τον κίνδυνο ανάπτυξης διαβήτη κύησης. Ο ρόλος του μεταβολικού προφίλ και της ψυχικής υγείας της μητέρας: δεδομένα από τη μελέτη Ρέα, Κρήτη.
Author Χαλκιαδάκη, Άννα
Thesis advisor Λιονής, Χρήστος
Reviewer Χατζή, Λήδα
Βαφειάδη Μαρίνα
Μαργετάκη, Κατερίνα
Abstract Introduction: GDM is among the most common medical disorders of the perinatal period affecting up to 21% of women globally. Maternal diet seems to play a significant role in the development of the GDM. Hypothesis: Unhealthy eating patterns and depression symptoms during pregnancy increase the risk of GDM by the modification of maternal metabolic profile. Aim: To examine the associations between maternal diet during pregnancy and the risk of developing gestational diabetes mellitus in a sample of women from the “Rhea” mother-child cohort. In addition, the role of maternal metabolic profile and depression symptoms will be examined. Methods: The present study is part of the prospective “Rhea” mother-child cohort. Questionnaires were used to collect information about maternal dietary habits and mental health. Women were screened for GDM by the 100-g 3-h oral glucose tolerance test (OGTT) at weeks 24–28 of gestation. Urinary metabolites were measured using Proton nuclear magnetic resonance (1H NHR) spectrometry. Results: It was found no significant association between any dietary pattern (Western type, Heathy type and MedDiet) and GDM, even after adjusting for potential confounders. Also, no significant association was found between EPDS score and GDM, even after adjusting for potential confounders. Higher compliance to Western type dietary pattern was associated with a reduction in the likelihood of GDM by the interaction of glycine and lysoPC a C18:0 (OR (95% CI) = 0.99 (0.99, 1.00) p=0.013). Higher compliance to Healthy type dietary pattern was associated with a higher likelihood of GDM by the interaction of glycine and lysoPC a C18:0 (OR (95% CI) = 1.003 (1.00, 1.005) p=0.036). Higher compliance to MedDiet was associated with a reduction in the likelihood of GDM by the interaction of glycine and lysoPC a C18:0 (OR (95% CI) = 0.99 (0.99, 1.00) p=0.030). Conclusion: Maternal dietary patterns (Western type, Heathy type and MedDiet) and maternal mental health were not associated with the risk of GDM development in the current study. A negative association was observed between the Western type diet and isoleucine, alanine, leucine and valine. In addition, a negative association was observed between the MedDiet and LysoPC a C18:1. A positive association was observed between the Healthy type diet and alanine, isoleucine, leucine, valine and LysoPC a C18:1. Higher levels of glycine and LysoPCaC 18:0 were associated with a higher risk of GDM.
Language English
Subject Dietary assessment
Διατροφική αξιολόγηση
Issue date 2020-03-24
Collection   Faculty/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/8/6/a/metadata-dlib-1589789912-906326-18781.tkl Bookmark and Share
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