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Identifier 000442052
Title Delineating the role of Bone Marrow T regulatory cells in tumor growth and anti-tumor immunity
Alternative Title Διαλεύκανση του ρόλου των Τ ρυθμιστικών κυττάρων του μυελού των οστών στην ανοσολογική απάντηση έναντι της ανάπτυξης του όγκου
Author Μαρκάκη, Ευφροσύνη
Thesis advisor Βεργίνης, Παναγιώτης
Reviewer Παπαδάκη, Ελένη
Μπερτσιας, Γεώργιος
Abstract Over the past decade, regulatory T cells (Tregs) have received a tremendous amount of attention due to their ability to suppress the function of multiple types of immune cells restraining excessive immune responses and ensuring peripheral tolerance and overall maintenance of immune homeostasis. Recently, mounting evidence has revealed the presence of Treg cells in non-lymphoid tissues of both mice and humans where they control non immunological processes and contribute to a plethora of diseases. In the present study, we focused on Bone Marrow (BM) Tregs which until now remain poorly explored and their role in tumor development and anti-tumor immunity is really underestimated. By performing an extensive phenotyping and some functional experiments, we unraveled that BM Tregs exhibit a differential phenotypic and functional profile compared with the well-studied Tregs of lymph nodes upon tumor induction indicating that they constitute a special and distinct population of the Treg cell lineage which possibly affects the immune responses during tumor growth.
Language English
Subject Αντικαρκινική ανοσολογική απάντηση
Issue date 2021-07-29
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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