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Identifier 000442027
Title O ρόλος των φυσικών προϊόντων ως τροποποιητές επιγενετικών μηχανισμών με ογκολογικό ενδιαφέρον
Alternative Title Natural products as epigenetic modulators targeting anticancer therapeutics
Author Μαρκάτος, Χρήστος-Γεώργιος
Thesis advisor Ζερβού, Μαρία
Κρίτση, Ευτυχία
Γεωργιάδης, Παναγιώτης
Abstract Epigenetics refers to inherited changes in gene expression without any changes in DNA sequence. Epigenetic mechanisms include DNA methylation, post- translational histone modifications, readout of the modifications, chromatin remodeling, and regulation by non-coding RNAs. Epigenetic enzyme dysfunction, as well as their aberrant regulation / expression, have been shown to be involved in a wide range of diseases, including cancer. An important feature of epigenetics is the reversible nature of the epigenetic modifications and this reversibility establishes the involved enzymes as, promising therapeutic targets. In this review, epigenetic landscape and related regulators are presented as well as currently developed epigenetic drugs. Moreover, emphasis is laid on natural products that inhibit DNA methyltransferases (DNMTs) enzymes and histone deacetylates (HDACs) as well as other epigenetic regulators. Natural products can regulate the epigenome by regulating mechanisms and proteins that are responsible for chromatin remodeling. Natural compounds such as EGCG, curcumin, genistein, quercetin and resveratrol show potent anticancer activity by reversing epigenetic lesions associated with oncogene activation and inactivation of tumor suppressor genes. The ability of natural products to interfere and modulate epigenetic enzymes activity, makes them candidates as lead compounds for the development of new anticancer drugs, with significantly lower toxicity than already used epidrugs. However, most of the natural products that target epigenetic enzymes do not have isoform selectivity, which is important in determining their potential use as therapeutic agents. Nevertheless, the wealth of natural product scaffolds presented in this review may guide the development of specific inhibitors with fewer side effects for cancer treatment. Moreover, epigenetic alterations induced by natural products can be exploited towards the discovery of new biomarkers for cancer prevention, diagnosis and even prognosis.
Language Greek, English
Subject Αντικαρκινική θεραπεία
Επιγενετικοί μηχανισμοί
Μεθυλίωση DNA
Issue date 2021-07-29
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
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