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Identifier 000457166
Title The role of DNA damage in age-related inflammation
Alternative Title Ο ρόλος των γενετικών βλαβών στη φλεγμονή κατά τη γήρανση
Author Θεοδωράκης, Εμμανουήλ
Thesis advisor Γαρίνης, Γεώργιος
Reviewer Τσατσάνης, Χρήστος
Βεργίνης, Παναγιώτης
Abstract During aging, a multitude of changes occurs, directly affecting immune system integrity and creating an environment of low-grade, chronic inflammation irrespective of pathogen encounter. DNA damage plays a pivotal role in the process of cellular aging, triggering a cascade of stress responses that are sensed within the cell. Through intercellular communication, a series of phenotypic changes then emerge at a systemic level. Previous work in our lab by Goulielmaki et al. (2020) reveals that DNA-damage accumulation in macrophages creates a chronic inflammation environment whereby systemic alterations in metabolism occur. In this work, we aim to dissect how DNA damage in macrophages impacts on the function of CD4+ T cells
Language English
Subject Ageing
Lymphocytes
Βλάβες γενετικές
Λεμφοκύτταρα
Μακροφάγα
Issue date 2023-07-28
Collection   School/Department--School of Medicine--Department of Medicine--Post-graduate theses
  Type of Work--Post-graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/c/5/e/metadata-dlib-1689235423-256989-26124.tkl Bookmark and Share
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