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Identifier

000457818

Title

Ανοσοαπάντηση σε ογκολογικούς ασθενείς με μόλυνση SARS-Cov-2

Alternative Title

Immune response in oncology patients with SARS-CoV-2 infection

Author

Μαρινοπούλου, Δήμητρα

Thesis advisor

Σουρβίνος, Γεώργιος

Reviewer

Αγγελάκη, Σοφία
Ζουμπουρλής, Βασίλειος

Abstract

The 2019 coronavirus disease (COVID-19), which causes severe acute respiratory syndrome due to infection with the coronavirus 2 (SARS-CoV-2), has caused global concern in recent years. It is responsible for human infections, causing from asymptomatic to severe mental, acute respiratory syndrome and organ injury. Since both the innate and adaptive immune responses are involved in limiting infection, a significant inflammatory response is observed in severe cases. Lymphopenia, higher white blood cell count, and higher neutrophil count, combined with nonspecific markers such as lower albumin, higher prothrombin time, and higher D-dimer, which are commonly altered in cancer patients, are predictors of worse outcome during COVID-19[1 . ,2]. As all the studies presented show, the most vulnerable group of patients are patients with hematological malignancies and lung cancer. According to the studies, the following data that only a part of malignancy patients infected with SARS-CoV2 show that antibodies against SARS-CoV2 develop and even the seroconversion time is longer compared to the general population [3,4 ] . In particular, anticancer treatments were studied when the patient is suffering from the infection, as the collaborations are capable of leading to a worse outcome, such as chemotherapy [5]. Regarding solid tumors, the most common cancer subtype among patients with reinfection in the studies presented is lung cancer. It was found that patients with lung cancer had a higher risk of mortality during re-infection. Serum ferritin and creatinine values at re-infection were found to be significantly higher than at first infection and are now a biomarker for disease progression[2]. In addition, the effect of immunotherapy on patients with and infection by the virus was presented, as both burden the patient's immune system, concluding that it should not be done at the same time as the infection[1]. However, further monitoring and investigation of the effects of infection in these patients is imperative as cancer types and treatments play a large role in disease progression and protection.

Language

Greek, English

Subject

Antibodies

Malignancy

Ανοσολογική απόκριση

Αντισώματα

Issue date

2023-07-28

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses