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Identifier

000391311

Title

Μελέτη του ρόλου και του μηχανισμού δράσης των μικρονευροτροφινών στη ψωρίαση

Alternative Title

Evaluation of the role and the mechanism of action of microneurotrophins on psoriasis

Author

Παυλίδου, Άττικα

Thesis advisor

Βενυχάκη, Μαρία

Reviewer

Γραβάνης, Α.
Τσατσάνης, Χ.

Abstract

«Study of the role and mechanism of microneurotrofins in psoriasis» Psoriasis is a chronic inflammatory autoimmune skin disease, with a strongly negative effect on patients’ health, affecting 1-2 % of Caucasian population. The triggeging factors of this disease are multicausative, with a significantly role for many genes and stress factors affecting in a alterative way in different population, as well as an important impact of environmental factors. The histological appearance of psoriasis consists of 1) the named acanthosis, representing the demarked prolonged epidermis in psoriasis lesions, b) the parakeratosis, wich is defined as the thickening of the keratin layer in epidermis, with an abnormal differentiation of keratinocytes, and to conclude c) an increased angiogenesis and infiltration of inflammatory cells, such as neutrophils, CD4+ and CD8+ T cells, and dendritics cells, contributing to the pathogenesis of the disease. The neurosteroid dehydroepiadrosterone has been investigated widly in diseases classified as immunological disorders, demonstrating strong neuroprotective and immunomodulatory properties, even in skin disorders like atopic dermatitis. More precisely in psoriasis, DHEA has not been researched systematically, although first findings indicate low levels of this neurosteroid in patients with psoriasis. The exogeneous administration of DHEA has not been beneficial as the neurosteroid can be immediately converted into androgen and estrogen. BNN27 is synthetic analogue of DHEA wich seems to conserve the beneficial of DHEA in immunological disorders like in vivo model of multiple sclerosis and model of inflammatory pain, without being further converted into estrogen or androgen. Our study agrees with the previous one, demonstrating a dimitution of the pathological key points of the psoriasis, due to the administration of BNN27. In particular, we observed a reduction in the triggering of the immunological response, as dendritic cells(CD11c+) and antigen-presenting cells(MHC II+), as well as a decrease in wide range of T-cells subsets, as CD4+ and CD8+. As a result of this impairment, we showed that even the product of this immunological response as cytokines (IL-6, IL-17A) are decreased in the group administrated with BNN27, establishing a anti-inflammatory role for the DHEA analogue.

Language

Greek

Subject

DHEA

Microneurotrophins

Psoriasis

Μικρονευροτροφίνες

Ψωρίαση

Issue date

2015-03-31

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses