Post-graduate theses
Current Record: 749 of 1241
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Identifier |
000389102 |
Title |
Molecular and genetic study of the multiple signaling pathways of the p75 neurotrophin receptor in schwann cells |
Alternative Title |
Μοριακή και γενετική μελέτη των πολλαπλών σηματοδοτικών μονοπατιών του υποδοχέα νευροτροφίνων p75 στα κύτταρα schwann |
Author
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Δεληβανόγλου, Νικολέτα
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Thesis advisor
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Χαραλαμπόπουλος, Ιωάννης
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Abstract |
The p75 death receptor is a pan-neurotrophin receptor, belongs to TNFR
family and is expressed, both on neurons and glia, during development and adulthood
and it can be induced after nerve injury or/and disease. It has been extensively
described that p75NTR can mediate a variety of functions such as cell death, survival,
axonal growth, proliferation and myelination. In addition, p75NTR binds to all
neurotrophins and is the high-affinity receptor for the immature isoforms of
neurotrophins (pro-neurotrophins). It can also bind other non neurotrophic ligands
such as Aβ-amyloid, prion proteins (PrP) or myelin derived proteins such as myelinassociated
glycoprotein (MAG). Due to lack of intrinsic enzymatic activity, it
interacts with a plethora of intracellular proteins in order to activate different
signaling cascades. In structure-function studies has been established that different
ligands evoke different conformational changes of the receptor molecule that regulate
differentially the cellular response. Understanding of its physiology, genetic and
molecular biology may contribute to novel therapeutic approaches to malfunction of
the nervous system in pathological conditions. In this study, we investigated the
ligand-depended interaction between p75NTR and receptor-interacting protein 2
(RIP-2), an adaptor protein involved in cell survival in Schwann cells and we
demonstrate the potential protective role of two novel p75NTR ligands,
dehydroepiandrosterone (DHEA) and its synthetic analogue BNN27, in apoptosis.
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Language |
English |
Subject |
Apoptosis |
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Neurotrophin |
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Receptor-interacting protein |
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Schwann cells |
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p75 receptor |
Issue date |
2014-12-04 |
Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/0/4/1/metadata-dlib-1421944722-875999-15881.tkl
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