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Identifier

000388971

Title

Μεταβολές του μετρούμενου αξονικού μήκους του οφθαλμού σε παθήσεις της ωχράς κηλίδας

Alternative Title

Ocular axial length changes in macular diseases

Author

Αποστολίδη, Ιωάννα Κ.

Thesis advisor

Κυμιωνής, Γεώργιος

Reviewer

Παλλήκαρης, Ιωάννης
Τσιλιμπάρης, Μιλτιάδης

Abstract

PURPOSE To evaluate the changes of the axial length in patients with macular disease over the course of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment, in order to determine the potential impact on the power of the artificial intraocular lens implanted in the eye during cataract surgery. METHODS In this prospective study 40 patients (40 eyes) with macular edema underwent intravitreal anti-VEGF injection therapy and were followed for 2 months. The eyes without treatment were included as a control group (40eyes). The central retinal thickness was measured with optical coherence tomography (OCT) and the axial length on IOLMaster. The changes of the two test parameters and the correlation between them were analyzed with the statistical data analysis package SPSS 20 for Windows (SPSS, Inc., Chicago, IL, USA). The variables were also analyzed separately for diabetic and non-diabetic patients. The reanalysis was performed for the subgroup of patients who displayed change in Optical Coherence Tomography greater than 40 μm. RESULTS Central retinal thickness (CRT) of the injected eyes decreased by 33.23 ± 74.23 μm, while axial length (AL) increased by 0.009 ± 0.058 mm. In case of control eyes, CRT decreased by 16.63 ± 75.67 μm and AL increased by 0.022 ± 0.139 mm. Diabetics displayed decrease in CRT by 52.69 ± 73.44 μm and increase in AL by 0.024 ± 0.069 mm, while non-diabetics had decrease in CRT by 23.85 ± 74.14 μm and increase in AL by 0.002 ± 0.051 mm. Diabetic control eyes displayed decrease in CRT by 28.46 ± 50.81 μm and increase in AL by 0.049 ± 0.188 mm, while in non-diabetics we had decrease in CRT by 10.93 ± 85.40 μm and increase in AL by 0.009 ± 0.110 mm. - 6 - CONCLUSIONS Administration of anti-VEGF intravitreal injection therapy affects significantly the treatment of macular edema and leads to the decrease of central retinal thickness. However, it appears that this treatment does not affect significantly the change of biometry and the determination of the power of the implantable intraocular lens during cataract surgery, as CRT change does not correlate with AL change.

Language

Greek

Subject

Axial length

Central retinal thickness

Optical comerence tomography

Αντιαγγειογενετική θεραπεία

Αξονικό μήκος

Κεντρικό πάχος αμφιβληστροειδούς

Οπτική βιομετρία

Οπτική τομογραφία συνοχής

Issue date