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Identifier

000383209

Title

T regulatory cells in follicular fluid in women with fertility problems

Alternative Title

Ο ρόλος των Τ ρυθμιστών κυττάρων στο ωοθηλακιακό υγρό γυναικών με πρόβλημα υπογονιμότητας

Author

Λυκάκης, Ιωάννης

Thesis advisor

Μακρυγιαννάκης

Reviewer

Βεργίνης

Abstract

Infertility is a common disorder that involves both genders and it is found in 25% of couples. Female factor infertility which is the most common is associated with gynecological disorders such as polycystic ovary syndrome (PCOS) and endometriosis. CD4+ CD25+ regulatory T cells (Treg) is a subpopulation of T cells responsible for the modulation of immune system. A systematic expansion of Treg is observed during pregnancy and prevents fetal rejection. A lot of studies show the association of infertility with reduced levels of Treg cells. The aim of this research is to investigate the levels of Tregulatory cells in follicular fluid in infertility women. 74 samples were collected and divided in three group . The first group (24 samples) was women with polycystic ovary syndrome , the second (20 samples) was women with unexplained infertility and the third ( 30 samples ) was women with male factor infertility. Flow cytometry was performed in order to identified the levels of Tregulatory cells. The levels of CD4+posititve cells were significant higher in PCOS women comparing with unexplained infertility women and male factor, also the levels of activated Tregulatory cells are significant decreased comparing with male factor infertility. These results indicate that decreased levels of activated Tregutory cells may be associated with fertility problems in PCOS women. Introduction

Language

English

Subject

Infertility

T regulatory cells

Τ ρυθμιστικά

Υπογονιμότητα

Issue date

2013-07-16

Collection

School/Department--School of Medicine--Department of Medicine--Post-graduate theses

Type of Work--Post-graduate theses