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Identifier

000388656

Title

Ανάπτυξη μοντέλου υπερτονίας σε πειραματόζωα

Alternative Title

Development model of hypertonicity to animals

Author

Χατζηδάκη, Άννα

Thesis advisor

Γκίνης, Χαρίλαος

Reviewer

Τσλιμπάρης, Μιλτιάδης
Δετοράκης, Ευστάθιος
Ταρουδάκης, Μιχάλης

Abstract

Glaucoma is the whole pathology of the eye, which have the common finding of increased intraocular pressure to such an extent as to cause damage to the optic nerve and discounts of the field. In many cases patients remain asymptotic happen until serious vision loss more often than not no way to recovery. In most cases the optic nerve is damaged from high intraocular pressure and to reduce the target all existing treatments (medications, laser, surgery). The increase in intraocular pressure more often due to obstruction of drainage of a fluid produced inside the eye, the aqueous humor. The aqueous humor is constantly produced and drained so if for some reason blocked the drain, then increased intraocular pressure. The purpose of the present thesis was to develop an animal model of ocular hypertension in rabbits, by reducing the outflow facility. In particular, a solution of glass microspheres (1-20μm in diameter), was injected in the anterior chamber of the each eye. The intraocular pressure was followed for an interval up to four months with Tonopen XL (portable electronic tonometer) and compared to baseline intraocular pressure (prior to microsphere injection). By using a purposely developed microdosage-pressure sensing device the ouflow facility and ocular rigidity were measured. These parameters are associated with ocular elasticity and hydrodynamics of the eye. The drainage of aqueous fluid as a function of intraocular pressure is described by outflow facility coefficient, while a 6 measure of the elastic properties of the eye, the ocular rigidity coefficient describes the pressure- volume relationship of the eye. Finally, a selective number of eyes underwent histological examination for the detection of microspheres in the anterior chamber and trabeculum. In this study, the increase of intraocular pressure following intracameral injection of glass microspheres was documented. Additionally, an increase of ocular rigidity and a reduction of the outflow facility coefficient was observed in the experimental eyes. Histopathological analysis of the eyes revealed microspheres in the trabeculum with no significant inflammatory reaction.

Language

English

Subject

Aqueous humor

Glaucoma

Histology

Intraocular pressure

Ocular Rigidity

Outflow facility

Tonepen

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