Post-graduate theses
Current Record: 40 of 1241
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Identifier |
000460760 |
Title |
Developing a system to study multimodal association of stimuli in mice |
Alternative Title |
Ανάπτυξη συστήματος για τη μελέτη πολυτροπικής συσχέτισης ερεθισμάτων στο ζωικό μοντέλο των μυών |
Author
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Βαρβούτη, Δήμητρα
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Thesis advisor
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Φρουδαράκης, Εμμανουήλ
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Reviewer
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Ποϊράζη, Παναγιώτα
Παπουτσή, Αθανασία
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Abstract |
Associating
various sensory information to visual objects is a fundamental cognitive process that
enhances the ability to recognize objects and improves memory performance. Mice are capable of
invariant object recognition in their natural environment , however the associated changes of object
manifolds along the cortex remain widely unknown. We suggest a new approach by establishing
multimodal association of stimuli to determine if there is an overlap between neuronal populations
who respond to different properties of the same object. Specificall y, the question we are trying to
address is whether the manifold of an object is formed in V1 area, while the mouse is exposed to
an associated odor, giving us a chance to better identify which subgroup of neurons are actually
responsible for object recognition. Using home cage training, we examined the ability of two
different strains of mice ( C57BL/6 J & Thy1 GCaMP6 ) to associate a visual object with an odor.
We found differences between strains during the behavioral training while propos ing three
different experimental paradigms (Go/ 2AFC , M2S in order to conclude which is the most
suitable. Furthermore, we finely tuned several different parameters that play a significant role in
automated behavioral training. Overall, it was challenging to establish such an association while
ensuring that the animals consider both stimuli to make decisions.
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Language |
English |
Subject |
Mental imagery |
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Object recognition |
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Promary visual cortex |
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Αναγνώριση αντικειμένου |
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Πολυτροπικός |
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Πρωτογενής οπτικός φλοιός |
Issue date |
2023-12-08 |
Collection
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School/Department--School of Medicine--Department of Medicine--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/a/2/6/metadata-dlib-1701342049-216915-16259.tkl
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Views |
1105 |