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Identifier

000463388

Title

Chronic stress and glucocorticoid receptor signaling in adult hippocampal neurogenesis and astrogliogenesis in Tau pathology

Alternative Title

Η επίδραση του χρόνιου στρες και της σηματοδότησης του υποδοχέα των γλυκοκορτικοειδών στην νευρογένεση και την αστρογλοιογένεση στον ενήλικα ιππόκαμπο σε μοντέλο παθολογίας Tau

Author

Γρατσία, Ειρήνη

Thesis advisor

Σωτηρόπουλος, Ιωάννης

Reviewer

Χαραλαμπόπουλος, Ιωάννης
Ζαγανάς, Ιωάννης

Abstract

One of the main brain regions that controls memory and is affected in the early stages of Alzheimer's disease (AD) is the hippocampus with its dentate gyrus (DG) subregion being involved in the input information flow from other brain regions and combines newborn and pre-existing neurons, astrocytes and microglia. Chronic stress is considered a major risk factor for AD through the deleterious effects of elevated levels of glucocorticoids (GC) that activate cellular mechanisms of AD pathology e.g. hyperphosphorylation and toxic aggregation of Tau protein. However, the effect of chronic stress on DG in AD pathology remains unclear. Thus, these Master studies aim to understand the effect of chronic stress and the interaction between different types of newborn and pre-existing cells of DG in Tau pathology. Our findings show the essential contribution of neuronal, but not microglial, glucocorticoid receptors in the stress-induced reduction of neurogenesis and astrogliogenesis in DG in Tau brain pathology. These findings provide new information on the detrimental effect of chronic stress on the complex neuron-microglia interaction that impairs DG plasticity in Tau pathology

Language

English

Subject

Adult brain

Astrocytes

Cytogenesis

Denatate gyrus

Microglia

Neurons

Tau protein

Tau πρωτεϊνη

Αλτσχάιμερ