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Doctoral theses

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Identifier uch.med.phd//1995DIS0064
Title Έκφραση ογκογονιδίων, ιού της ηπατίτιδας Β και νεοπλασματικών δεικτών (ορού /ιστών) στο ηπατοκυτταρικό καρκίνωμα του ανθρώπου
Creator Nikolaidou, Anastasia J
Abstract The aim of the present thesis was to investigate the relationship of the expression of C-MYC, RAS and C-ERBB-2/NEU oncogenes and the genetic alterations of KI-RAS oncogene and P53 tumour-suppressor gege to the presence of markers of hepetitis B virus(HBV) infection and tumour markers in human hepatocellular carcinama(HCC). Increased MYC P62 oncoprotein expression was detected in 48% of well differentiated HCC, while enhanced expression of RAS P21 and ERBB-2P185 was found in 75% and 61% of HCC. Twenty two(53.65%) HCC were shown to contain integrated HBV DNA, while 7(17.1%)and 5(12.2%)HCC were shown to carry codon 249P53 and codon 12KI-RAS gene mutations respectively.
Language Greek
Issue date 1995-06-01
Date available 1997-06-06
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/2/d/c/metadata-dlib-1995DIS0064.tkl Bookmark and Share
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