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Identifier uch.med.phd//1994DIS0049
Title Ο ρόλος των CD8 λεμφοκυττάρων στην εμφάνιση ουδετεροπενίας στους πάσχοντες από χρόνια Β-λεμφοκυτταρική λευχαιμία
Alternative Title The role of CD8+ lymphocytes in the determination of neutropenia in patients with B-cell chronic lymphocytic leukemia
Creator Katrinakis, George D
Abstract We studied 34 patients with B-CLL, regarding the changes in neutrophil counts to demonstrate the involvement of CD8+ lymphocytes in the determination of the neutropenia which some of them develop. A linear negative, statistically significant correlation was found between numbers of CD8+ lymphocytes and circulating neutrophils. Furhtermore, the highest values of colony-format inhibition were taken from in vitro cultures by normal CFU-GM cells in the presence of CD8+ lymphocytes of neutropenic patients compared to the correlation of TNF-A lavels, in serum and in supernatants of CD8+ cells liquid cultures among neutropenic patients, non neutropenic patients and normal subjects did not demonstrate the involvement of TNF-A in the determination of neutropenia.(abstract truncated)
Issue date 1994-03-01
Date available 1997-06-6
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/2/4/a/metadata-dlib-1994DIS0049.tkl Bookmark and Share
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