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Identifier

000456455

Title

Προγνωστικοί παράγοντες εμφάνισης και δυνατότητας πρόληψης του μετεγχειρητικού υποπαραθυρεοειδισμού

Alternative Title

Early postoperative parathormone and calcium as prognostic factors for postoperative hypocalcemia

Author

Δασκαλάκη, Άννα

Thesis advisor

Χρυσός, Εμμανουήλ

Reviewer

Λασηθιωτάκης, Κωνσταντίνος
Νότας, Γεώργιος

Abstract

Background: Postoperative hypocalcemia is one of the most common complications after total thyroidectomy. Parathormone (PTH) and calcium levels, measured several hours after surgery, have been suggested as valuable markers for detecting patients at risk for post-thyroidectomy hypocalcemia. We aimed to determine if early post-operative PTH and calcium levels can be used for the early identification of patients at risk for symptomatic hypocalcemia. Methods. PTH and calcium were measured before surgery and at 10 min and 4 h post-thyroidectomy, in 87 patients. Performance characteristics of PTH and calcium levels and their post/pre-operative ratios were calculated. Results: Four-hour calcium was a sensitive (93.75%) but not specific (67.61%) indicator of patients at risk for symptomatic hypocalcemia. The 4-h/pre-operative PTH ratio was the most accurate (90.81%) and the most specific (94.37%) test to identify patients at risk. Serum calcium at 4-h, 4-h/pre-operative PTH ratio, and PTH at 10 min post-operative had the higher diagnostic odds ratios (50.86, 32.85, and 29.04, respectively). The 4-h/pre-operative PTH ratio also had the highest (0.694) Youden’s J statistic. Conclusions: Low serum calcium levels 4 h after thyroidectomy and the 4-h/pre-operative PTH ratio could be valuable additions to everyday clinical practice in post-thyroidectomy patients.

Language

Greek, English

Subject

Ασβέστιο

Θυρεοειδεκτομή

Μετεγχειρητικά

Παραθορμόνη

Τηρυοιδεψτομυ

Υπασβεστιαιμία

Issue date

2023-07-28

Collection