Doctoral theses
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Current Record: 47 of 1070
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| Identifier |
000453717 |
| Title |
Ο ρόλος του ρινικού επιθηλίου στη διαμόρφωση της μη-ειδικής ανοσιακής απάντησης σε ασθενείς με αλλεργική ρινίτιδα |
| Alternative Title |
The role of NASAL epithelium in the formation of non-specific immunity in patients with allergic rhinitis |
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Author
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Σταματάκη, Σοφία
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Thesis advisor
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Προκοπάκης, Εμμανουήλ
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Reviewer
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Παπαδόπουλος, Νικόλαος
Ξεπαπαδάκη Παρασκευή
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| Abstract |
Background -Aim of study
Allergic rhinitis affects nearly 20-30% of world population and its associated with a considerable medical and socioeconomic burden. Despite the extensive research there are still many gaps of understanding of its pathophysiology. Recently, the role of nasal epithelium and innate immunity and their correlations with allergic rhinitis have gained much attention. Nasal epithelium is the first defense barrier against invaders and consist a major component and regulator of innate immunity with many different mechanisms such as secreting a cataract of cytokines and chemokines. This mediators induce a persistent local inflammation in nasal epithelium by attracting inflammatory cells and ultimately damaging the epithelial barrier. Many studies show that damaged epithelial barrier plays a key role in the pathophysiology of allergic rhinitis.
This study aims to study and compare the spontaneous release of epithelial cytokines and chemokines in different age groups from donors with allergic rhinitis and control group.
Methodology: 59 adults and children (0-45 years old) were enrolled in this study following strict inclusion criteria. A specialist assessed the participants with a detailed questionnaire, clinical examination and allergic tests when necessary. Primary epithelial cells from 47 donors (14 allergic and 33 non allergic) where successfully cultured and their unstimulated supernatants were analyzed with the Luminex technology for 21 cytokines and chemokines which play significant role in important immune pathways.
Results: Demographic data analysis and comparison between the two groups showed that the AR group was older following the hypothesis of “atopic march”. Disappointing was that the allergic rhinitis group was more exposed to cigarettes smoke. The AR was sensitized to multiple, common in Greece, aeroallergens. Interestingly, the AR group was found to have prone to viral infections (more episodes-longer duration).
The statistical analysis of the spontaneous release of epithelial cytokines and chemokines showed significant differences between the two groups. The levels of GMCSF, MIP1A, MIP1B, IL28A, TNFA, CCL5 were significant lower in the AR group. Most differences were found in the younger (0-12 years old) group of AR patients. These cytokines and chemokines participate in multiple immune pathways.
Conclusions: Despite the cross-sectional nature of the study and the limited number of subjects, allergic rhinitis appears to be associated with dysfunction of cytokine and chemokine spontaneous release from nasal epithelial cells which may represent an abnormal innate immunity maturation pattern. Further studies are needed to elucidate the role of nasal epithelial cells in the mechanism of AR which may lead in better treatment strategies.
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| Language |
Greek |
| Subject |
Μη ειδική ανοσία |
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Ρινικό επιθήλιο |
| Issue date |
2023-04-05 |
| Collection
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School/Department--School of Medicine--Department of Medicine--Doctoral theses
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Type of Work--Doctoral theses
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| Permanent Link |
https://elocus.lib.uoc.gr//dlib/5/6/a/metadata-dlib-1675336227-196343-23250.tkl
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| Views |
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