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Identifier uch.med.phd//1997DIS0120
Title Αλληλεπιδράσεις του πυρηνικού φακέλου με τη χρωματίνη: Βιοχημικός χαρακτηρισμός παραγόντων που συνδέουν την έσω πυρηνική μεμβράνη με τη χρωματίνη
Alternative Title Interactions of the nuclear envelope with chromatin: Biochemical characterization of the machinery that connects the inner nuclear membrane with chromatin
Creator Pyrpasopoulou, Athina M
Creator Pyrpasopoulou, Athina M
Contributor Τμήμα Ιατρικής
Abstract Morphological studies have established a close association of peripheral heterochromatin with the nuclear envelope, which has been attributed both to nuclear lamin and lamin-asociated proteins. It remains to be determined which of these elements are essential and which play an auxiliary role in nuclear envelope -chromatin interactions. To address this question, we used in vitro reconstituted vesicles assembled from octyl glucoside solubilized nuclear envelopes as a model system. Comparison of the chromosome-binding properties of normal, immunodepleted and chemically extracted vesicles led to the conclusion that the principal chromatin anchorage site at the nuclear envelope is LBR, a ubiquitous integral protein of the inner nuclear membrane. Consistent with this interpretation, purified LBR binds directly to chromatin fragments and decorates the surface of chromosomes in a pattern highly reminiscent of Q-banding
Physical description 130
Language Greek
Subject : 1. πυρηνικός φάκελος 2. ανοσοαφαίρεση 3. λαμίνες 4. διαμεμβρανικές πρωτεϊνες 5. χρωματίνη 6. επανασχηματισμός του πυρηνικού φακέλου 7. διαλυτοί παράγοντες του κυτταροπλάσματος 8. nuclear envelope 9. immunodepletion 10. lamins 11. intergral membrane proteins 12. chromatin 13. nuclear reassembly 14. soluble factors
Issue date 1997-01-01
Date available 1997-06-6
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Notes Committee Member Ανάγνου, Νίκος
Committee Member Γεωργάτος, Σπύρος
Committee Member Δελίδης, Γιώργος
Committee Member Θεοδωρόπουλος, Παναγιώτης
Committee Member Θερμού, Κυριακή
Committee Member Καραγωγέως, Δόμνα
Committee Member Καστανάς, Ηλίας
Number of References 136
ΥΠΑΡΧΕΙ ΠΑΡΑΡΤΗΜΑ
Permanent Link https://elocus.lib.uoc.gr//dlib/9/d/3/metadata-dlib-1997DIS0120.tkl Bookmark and Share
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