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Identifier

uch.med.phd//1996DIS0105

Title

Η κοιλιακή ωχρά σφαίρα ως υπόστρωμα ανταμοιβής

Alternative Title

The role of the ventral pallidum in reward

Author

Παναγής, Γεώργιος Θ

Abstract

In the present study the role of the ventral pallidum (VP)in self-stimulation behavior was examined in ratw. The distribution of electrical self-stimulation foci within the ventral pallidum was mapped using moveable electrodes. Our results show that 98% of VP sites supported self-stimulation behavior. A comparable high rate of positive sites was not obtained from adjacent brain areas. The estimation of poststimulation excitability of ventral pallidum neurons point to the suggestion that the self-stimulation substrate in the VP involves heterogeneous neurons.These excitability properties are different from those characterising catecholaminergic neurons. Studies using the psychophysical technique of collision show that the VP and the ipsilateral lateral hypothalamus and the ipsilateral or contralateral ventral tegmental area share no common reward fibres. Immunohistochemical studies show that rewarding electrical stimulation of the VP increased c-fos expression in several structures known to participate in the regulation of reward, such as the medial prefrontal cortex, the nucleus accumbens, the intermidiate aspect of the lateral septum,the prosterior lateral hypothalamus and the ventral tegmental area and failed to do so in structures devoid of such involvement(dorsolateral striatum and substantia nigra reticulata).

Language

Greek

Issue date

1996-12-01

Date available

1997-06-06

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

Permanent Link

https://elocus.lib.uoc.gr//dlib/3/7/9/metadata-dlib-1996DIS0105.tkl

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