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Identifier uch.med.phd//1996DIS0084
Title Νόσος του Crohn. Επιδημιολογική και κλινικοεργαστηριακή μελέτη στον νομό Ηρακλείου
Alternative Title Crohn'S disease. Epidemiological and clinical study in Heraklion
Creator Koutroubanis, John E
Abstract Objective : To study the incidence of Crohn's disease and to analyze the pattert of the disease in the prefecture of Heraklion, Crete. Another purpose of this investication was to study the -308 polymorphism of the TNF-a gene in relation to Crohn's disease. Method : A five year prospective and population based epidemiological study of Crohn's disease was carried out in well defined area of Crete. The study of the TNF-a gene polymorphism was done according to original report of this polymorfism. Results : The mean annual incidence of the disease for the years 1990-1994 was 3.0 per 10 to the 5 inharitants. During the study period the incidence incresed from 1.9/10 to the 5th in 1990 to 3.8/10 to the 5th in 1994.The male to female ratio was 2.4:1. The age group 25-34 year presented the highest age adjusted (6.3/10to the 5th). The incidence of Crihn's disease was also found to be higher in smokers, in urban areas and in people with high educational level. The two different alleles of TNF-a in Crohn's disease patients were not different in comparison to healthy controls. Conclusion:Crohn's disease is common in Heraklion, Crete.The findings of the study are discussed in relation to those of other European countries. The genetic susceptibility of Crohn's disease does not related to the TNF-a gene polymorphism.
Issue date 1996-08-01
Date available 1997-06-6
Collection   School/Department--School of Medicine--Department of Medicine--Doctoral theses
  Type of Work--Doctoral theses
Permanent Link https://elocus.lib.uoc.gr//dlib/a/2/0/metadata-dlib-1996DIS0084.tkl Bookmark and Share
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