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Doctoral theses

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Identifier

uch.med.phd//1992DIS0058

Title

Φωτοδυναμική θεραπεία πειραματικού ενδοφθαλμίου μελανώματος με τη χρήση τετρασουλφονιωμένου φθαλοκυανιδίου του αργιλίου

Alternative Title

Photodynamic therapy for experimental intraocular melanoma using chloroaluminum sulfonated phthalocyanine

Creator

Panagopoulos, John A

Abstract

Chloroaluminum sulfonated phthalocyanine (CASPC), a novel photosensitizing dye, was evaluated for treatment of experimental intraocular melanoma in 33 rabbit eyes. An argon ion pumped dye laser operating at an emission of 675 nm, was used in a nonthermal mode to irradiate iris tumors in rabbits 24 hours after they received and intravenous dye injection(23 eyes). The effects of laser irradiation alone and dye alone were examined in the control eyes. A threshold tumoricidal dose was established for photodynamic therapy with CASPC and laser irradiation. Tumors succesfully treated with CASPC and laser irradiation were arrested in growth and exhibited no viable tumor cells on histologic examination. Control tumors continued rapid growth, unaffected by dye or laser. Our data indicate that CASPC is a potential photosentisizing compound that may be useful in the treatment of choroidal melanoma.

Issue date

1992-06-01

Date available

1997-06-6

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

Permanent Link

https://elocus.lib.uoc.gr//dlib/8/2/4/metadata-dlib-1992DIS0058.tkl

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