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Doctoral theses

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Identifier

uch.med.phd//1994DIS0041

Title

Ο ρόλος του ογκο-κατασταλτικού γονιδίου P53 και του ογκογονιδίου Ras στον καρκίνο του ανθρώπου. Ειδική αναφορά στον καρκίνο του μαστού, του πνεύμονα, της κεφαλής και του τραχήλου

Alternative Title

Role of the P53 oncosuppressor gene and Ras oncogenes in breast, lung and head and neck cancer

Creator

Malliri, Aggeliki Ch

Abstract

In the present thesis the expression of the P53 tumors suppresor gene and RAS oncogene were examined in breast corcinomas, squamous cell carcinomas of the head and neck and in non-small cell lung carcinomas. P53 and RAS P21 alterations were found to be a common event in the development of the above tumours. Mutations in the P53 gene are a late event in the development of breast cancer. A significantly higher number of P53 stained breast cancer specimens were overexpression the RAS gene. P53 overexpression was also found to correlate with a poor prognosis in lung cancer patients as well as with the smoking history of head and neck patients.

Issue date

1994-00-01

Date available

1997-06-6

Collection

School/Department--School of Medicine--Department of Medicine--Doctoral theses

Type of Work--Doctoral theses

Permanent Link

https://elocus.lib.uoc.gr//dlib/8/7/4/metadata-dlib-1994DIS0041.tkl

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