Your browser does not support JavaScript!

Home    Collections    Type of Work    Graduate theses  

Graduate theses

Current Record: 14 of 1622

Back to Results Previous page
Next page
Add to Basket
[Add to Basket]
Title The role of epigenetic factors on metabolism in the nematode Caenorhabditis elegans
Alternative Title Ο ρόλος των επιγενετικών παραγόντων στον μεταβολισμό του νηματώδους Caenorhabditis elegans
Author Γιαννοπούλου, Μαγδαληνή
Thesis advisor Ταβερναράκης, Νεκτάριος
Μπαζοπούλου, Δάφνη- Μαρία
Abstract In the field of molecular biology, the causal relationship between chromatin changes and lipid metabolism has gathered significant attention. Chromatin, the scaffold of our genetic code, can undergo multiple chemical and structural modifications that are tightly intertwined with metabolic processes. Dietary habits and food intake may introduce not only essential nutrients but also epigenetic modulators, that can greatly impact the epigenetic landscape of the organism. Interestingly, lipids do not only serve as vital energy reservoirs, but also act as signaling molecules, orchestrating a plethora of cellular pathways and influencing various physiological processes. Concomitantly, lipids modulate epigenetic control of metabolism, creating a feedback loop, wherein metabolism directs lipid fate, which then reciprocally affects epigenetic modifications, sustaining a cycle of a dynamic equilibrium. Despite the growing understanding of this interdependence, the role of specific epigenetic factors in regulating genes associated with metabolic processing of lipids, in particular monounsaturated fatty acids, remains an area warranting deeper exploration. Here, we recruit C. elegans strains, including N2 wild-type and epigenetic regulator knockouts, to investigate the effects of a high-fat diet on longevity and mitochondrial homeostasis. Under high-fat dietary conditions, the N2 strain exhibited reduced mean lifespan, whereas the knockout strains showed resilience. Additionally, mutant strains displayed a significant reduction in mitochondrial reactive oxygen species levels upon high-fat diet treatment, contrary to the N2 strain. These observations, while insightful, represent only a fragment of a broader scientific enigma surrounding metabolism and epigenetics. Unraveling these mechanisms could potentially lead to the development of novel therapeutic approaches targeting multiple metabolic disorders, like obesity and its adverse effects.
Language English
Issue date 2023-11-24
Collection   School/Department--School of Sciences and Engineering--Department of Biology--Graduate theses
  Type of Work--Graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/3/8/e/metadata-dlib-user1698887616-9966.tkl Bookmark and Share
Views 197

Digital Documents
No preview available

Download document
View document
Views : 7