Your browser does not support JavaScript!

Home    Collections    Type of Work    Graduate theses  

Graduate theses

Current Record: 3 of 1381

Back to Results Previous page
Next page
Add to Basket
[Add to Basket]
Title Διερεύνηση και συσχέτιση της επιβάρυνσης μητέρας-νεογνού σε ουσίες με πιθανή ενδοκρινική δράση
Alternative Title Investigating and correlating the maternal-neonatal burden on substances with possible endocrine activity
Author Τσαγγαρίδου, Στέφανη
Thesis advisor Ρίζος, Απόστολος
Τζατζαράκης, Εμμανουήλ
Abstract Endocrine disruptors are substances that can be found everywhere in our daily life making almost impossible the avoidance of contacting with them. Endocrine disruptors are exogenous compounds or mixtures of compounds that can cause adverse effects on the health of an organism or its progeny. These effects are due to changes that are caused in endocrine function. Children, especially new-borns, are more sensitive to these substances than adults because metabolic pathways are incomplete during the first months of life. Newborns’ system metabolizes, detoxifies and eliminates unwanted substances in a different way than adults do, resulting in being more vulnerable to health problems. Current study aimed to evaluate the levels of DTTs, Parabens, Triclosan (TCS) and Bisphenols A, S in both maternal and neonatal hair and examine whether there are any correlations between them. In addition, the changesin the children’s’ burden aged 6-12 months were also evaluated. Hair samples were collected from 39 mothers and 44 newborns. Two samples were collected from some of the newborns. The first sampling was obtained immediately after the birth and the second sampling was obtained between the 6th to 12th months of age (12 children). The hair samples were recorded in accordance with their length, weight and colour. Solid-liquid extraction with methanol was used for samples processing. For the analysis of parabens, bisphenols and TCS liquid chromatography (LC) coupled with mass spectrometry (MS) were utilized. As for organochlorinated substances (DDTs, HCB), a gas chromatography (GC) coupled with mass spectrometry (MS) were used. Hair sample analysis revealed that MenPB, ProPB, TCS and ppDDE had higher positivity rates 90-100%, than op DDD and ppDDD + op DDT which had lower rates with 0-30%. The burden was evident since the concentrations of lipophilic compounds (TCS, DDE, DDD, DDT, HCB) were increased in newborns samples compared to the samples obtained from the mothers and children. At the same time, parabens concentration levels in mothers’ samples were higher while those of bisphenols were higher in children's samples 6th to 12th months of age
Language Greek
Issue date 2021-07-30
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Graduate theses
  Type of Work--Graduate theses
Permanent Link https://elocus.lib.uoc.gr//dlib/e/3/0/metadata-dlib-1625640585-281289-16401.tkl Bookmark and Share
Views 69

Digital Documents
No preview available

No permission to view document.
It won't be available until: 2024-07-30