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Title Development of small molecule libraries for inhibition of ALOX15 enzyme
Author Πολατίδου, Κατερίνα
Thesis advisor Ελευθεριάδης Νικόλαος
Abstract In this thesis libraries of small molecule for inhibition of 15-lipoxygenase type 1, were designed. ALOX15 or 15-lipoxygenase type 1 enzyme, is implicated in many serious diseases such as anaphylactic diseases, asthma, COPD, diabetes, neurodegenerative diseases, certain types of cancer and many others due to the production of pro- and anti-inflammatory metabolites. Because, the existing potent 15-lipoxygenase-1 inhibitors have undesirable properties, the aim of this thesis was to find new scaffolds that possess good inhibitory potency. In order to achieve that, we designed a library of compounds synthesized by medicinal chemistry groups and organic chemistry groups that synthesize natural products. Also, a library of the known inhibitors of ALOX15, with known activities was developed and used as a control for our experiments. Then, docking studies were conducted using the rabbit ortholog model of 15-lipoxygenase-1 (PDB-ID; 2P0M) to filter through these compounds and propose the best ones to continue with in vitro inhibition studies.
Language English
Issue date 2022-11-24
Collection   School/Department--School of Sciences and Engineering--Department of Chemistry--Graduate theses
  Type of Work--Graduate theses
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