Post-graduate theses
Current Record: 4740 of 6695
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Identifier |
000373685 |
Title |
Ελεγχόμενη αποδέσμευση φωσφονικών φαρμάκων ακινητοποιημένα σε κατιοντικές πολυμερικές μήτρες |
Alternative Title |
Controlled release of phosphonate pharmaceuticals immobilized on cationic polymeric matrices |
Author
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Πασπαλάκη, Μαρία Εμμ.
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Select a value
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Δημάδης, Κωνσταντίνος Κ.
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Abstract |
The present thesis deals with the development of a controlled release system which could
be used in pharmaceutical applications. Specifically, we attempted to immobilize anionic
phosphonates onto cationic polymeric matrices and, furthermore, we examined the rate of
phosphonate release from these polymeric matrices. The anionic phosphonates HEDP
(hydroxyethylidene-diphosphonate) and EDTMP (ethylenediamine-tetrakis
(methylenephosphonate)) are prospective drugs for calcium deposition diseases and the
cationic polymers PEI (polyethyleneimine) and PDC (poly(diallyldimethylammonium
chloride)) represent the polymeric matrices.
When the above phosphonates react with the polymers, a complex salt is produced which is
formed due to the electrostatic interactions between the polycation and the phosphonate.
After synthesizing such complexes in various pH regions, they were characterized by using
FT-IR spectroscopy, the phosphorus content was determined and, finally, tablets containing
the synthesized complex were prepared and placed in a solution similar to the stomach
environment. Then we studied the release of the phosphonates every one hour for 8 hours.
In order to determine the concentration of the phosphonate released we used the HACH
method in which a blue complex is produced after the reaction of phosphates with
ammonium molybdate. The higher the concentration is the more intense the blue colour is.
We tried to succeed controlled and slow release of the phosphonates from the polymeric
matrices. Not all the complexes succeeded our purpose but some of them did. Those were
the complexes with PEI and HEDP. Finally, efforts were made to establish the controlled
release by using 1H and 31P NMR spectroscopy.
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Language |
Greek |
Subject |
Bisphosphonates |
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Drug delivery |
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Etidronic acid |
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Osteoporosis |
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Polyethylenic |
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Polymers |
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Διφωσφονικά |
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Ετιδρονικό οξύ |
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Μεταφορά φαρμάκων |
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Οστεοπόρωση |
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Πολυαιθυλένια |
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Πολυμερή |
Issue date |
2011-12-20 |
Collection
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School/Department--School of Sciences and Engineering--Department of Chemistry--Post-graduate theses
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Type of Work--Post-graduate theses
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Permanent Link |
https://elocus.lib.uoc.gr//dlib/e/1/d/metadata-dlib-1335934211-354191-15774.tkl
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Views |
379 |